Together, our data demonstrating the abundant transcript of SARM1 in photoreceptors, SARM1’s ability when overexpressed to induce photoreceptor cell death in vitro, and the evidence for an as yet unknown cell death pathway in models of inherited retinal degeneration gave us confidence to ascertain whether genetic loss of SARM1 would delay photoreceptor cell death in the rho−/− mouse model of photoreceptor cell degeneration. The gene discussed is RHO; the disease is retinal degeneration.