SARM1 is activated by a diverse range of stimuli, and it remains to be investigated what stimuli in particular are activating SARM1 in photoreceptors in vivo in the rho−/− model and whether acquired retinal diseases such as age-related macular degeneration or retinal injuries such as retinal detachments use SARM1 in a similar manner. This evidence concerns the gene SARM1 and age-related macular degeneration.