Contrastingly, cells harbouring the common and clinically severe FMF allele MEFVM694V engaged the Pyrin inflammasome and secreted IL-1β and IL-18 in the presence of colchicine despite inhibition of microtubule dynamics.24 We hypothesised that determining the ratio of the released cytokines in the presence versus absence of colchicine may provide a robust and fast functional read-out to support functional stratification and diagnosis of FMF.24 The gene discussed is MEFV; the disease is familial Mediterranean fever.