The stringent BRB of the retinal vasculature is not expected to be regulated by VEGFA, however, in ocular disease such as retinopathy, the BRB may be broken down (Urias et al., 2017); in accordance, proliferative retinopathies are characterized by increased transvessel flow and edema (Campochiaro, 2015; Kim et al., 2016; Luo et al., 2011; Stahl et al., 2010a). The gene discussed is VEGFA; the disease is retinal disorder.