As the main binding protein of IGF-1, insulin-like growth factor binding protein-3 (IGFBP3) has been reported to be linked to pathogenesis of cancers by exerting tumor suppressor activity in breast cancer [18] and pro-tumor effects in oral squamous cell carcinoma [19] and lung cancer [20]. Here, IGFBP3 is linked to oral cavity squamous cell carcinoma.