As a critical platform regulating inflammatory responses, NLRP1 inflammasome has been reported to be involved in nociception [22] and some skin diseases such as vitiligo, lupus erythematosus, pemphigus vulgaris, and psoriasis [14, 23, 24, 49, 50] Also, pro-inflammatory cytokine IL-1β and IL-18 have been reported to contribute to the development of contact hypersensitivity reactions and chronic itch [51–53]. Here, IL18 is linked to lupus erythematosus.