The 10% most abundantly expressed circRNAs were derived from genes demonstrating enrichment in the lysine degradation (p = 0.03), attenuation phase (p = 0.02), RUNX3 (p = 0.02), carcinoma (p = 0.01) and stem cell gene regulation (p < 0.001) pathways (Table 3). The gene discussed is RUNX3; the disease is carcinoma.