According to the maximum diameter of metastases (< 3 cm or > 3 cm), distribution of metastases (unilobar or bilobar), number of metastases (single or multiple), relapse time interval (< 6 months or > 6 months), age (< 60 years or > 60 years), carcinoembryonic antigen (CEA) level (< 10 ng/ml or > 10 ng/ml), time of liver metastasis (synchronous or metachronous), lymph node metastasis (yes or no), and preoperative chemotherapy (yes or no), propensity score analysis was used to analyze the effect of RFA on survival and recurrence. The gene discussed is CEACAM5; the disease is metastatic malignant neoplasm in the lymph nodes.