And l-CDL induced inhibition of p-TAK1, p-MAPK, NF-kB and proinflammatory cytokines were all could be reversed by NGF, indicating that l-CDL inhibited the upregulated NGF in CCI rats and downstream TAK1-MAPK/NF-κB signaling to alleviate CCI-induced neuropathic pain. This evidence concerns the gene NFKB1 and neuropathic pain.