FMR1 and fragile X-associated tremor/ataxia syndrome: We searched for all English language papers published between January 2001 and June 2019 in PubMed with the term (“Fragile X-associated Tremor Ataxia Syndrome” OR “FXTAS” and limited to case reports of patients who were (1) positive for premutation for the FMR1 gene and (2) described the clinical manifestations including tremor,ataxia,cognitive condition, parkinsonism and other symptoms in details especially about tremor.