In the study by Zhang, the protein and mRNA expression levels of chemokine-like factor-1, interleukin (IL)-6, IL-8, IL-18, and transforming growth factor (TGF)-β were higher in samples from keloid patients, compared with normal skin tissues and scar tissue.[3] Using the gene chip technology in combination, Chen et al found that some inflammatory factor-related gene expression was significantly up-regulated in keloid fibroblasts.[4]. This evidence concerns the gene IL6 and keloid.