NSE is expressed in nerves and cells of neuronal origin.[9] NSE is a well-established tumor marker for SCLC and serum NSE levels are significantly elevated in SCLC patients.[10] But serum NSE levels also higher in patients with non-small cell lung cancer and other types of tumor.[11] The association between serum NSE levels and gastric adenocarcinoma also has been previously reported, but the results were not consistent.[12,13] In the present study, serum NSE levels of gastric adenocarcinoma group and healthy control group were compared and analyzed. The gene discussed is ENO2; the disease is small cell lung carcinoma.