The contraindications of ozone therapy include: allergy to ozone, hyperthyroidism, deficiency of Glucose-6-phosphate Dehydrogenase (G6-PD), spinal canal stenosis, lateral recess stenosis, vertebral slippage, hemorrhagic disease, and severe hepatorenal insufficiency. This evidence concerns the gene G6PD and hyperinsulinemic hypoglycemia, familial, 4.