Because KMT2A regulates multiple Hox and Wnt related genes through histone H3 lysine 4 (H3K4) methylation,[11] phenotypes of the WDSTS patients are complex and involve multiple systems, including craniofacial features, skeletal anomalies,[12] organic problems, development and intellectual disability.[13,14]. This evidence concerns the gene KMT2A and Wiedemann-Steiner syndrome.