Moreover, similar reduction in hsCRP levels were observed regardless of variation in weight, suggesting that exercise training play a prominent role in inflammation reduction.[25] The positive impact of exercise training on the reduction of IL-6 and tumor necrosis factor α soluble receptor 1 levels was demonstrated in a group of patients with moderately severe and severe chronic heart failure and known ischemic heart disease.[67] The anti-inflammatory cytokine IL-10 primarily inhibits the release of tumor necrosis factor-α. This evidence concerns the gene TNF and congestive heart failure.