KCNH2 and familial long QT syndrome: All patients have typical features of the LQTS, and QTc in the resting 12-lead ECG of living affected members is more than 480 ms, which are consistent with criteria for LQTS proposed by Schwartz et al.[9] Furthermore, by using NGS and Sanger sequencing, we identified a novel deletion-frameshift mutation, c.381_408delCAATTT CGAGGTGGTGATGGAGAAGGAC, in exon 3 of KCNH2 gene in this Chinese family.