Recent observational studies have indicated favorable influences of healthy diets characterized by higher fruit and vegetable intakes on several biomarkers of inflammation, including C-reactive protein (CRP), interleukin-6 (IL-6), IL-10, and tumor necrosis factor-α (TNF-α),[8–10] and components of MetS.[11–13] However, studies based on experimental settings exploring the effects of healthy diets characterized by increased fruit and vegetables on markers of inflammation[14–16] and metabolic risk[17,18] have yielded inconclusive results. This evidence concerns the gene TNF and metabolic syndrome.