In addition, we found that genes ECM1, HAND2, PTGIS, SFRP1, SRPX, COLEC10, and GPR182 were significantly under‐expressed in LIHC in the Oncomine database, with the exception of DCN. Extracellular matrix protein 1 (ECM1) is expressed in the extracellular matrix of the liver, and knockout of ECM1 has been shown to lead to spontaneous and severe liver fibrosis in mice.24, 25. This evidence concerns the gene PTGIS and Hepatic fibrosis.