HAND2 and Hepatic fibrosis: In addition, we found that genes ECM1, HAND2, PTGIS, SFRP1, SRPX, COLEC10, and GPR182 were significantly under‐expressed in LIHC in the Oncomine database, with the exception of DCN. Extracellular matrix protein 1 (ECM1) is expressed in the extracellular matrix of the liver, and knockout of ECM1 has been shown to lead to spontaneous and severe liver fibrosis in mice.24, 25