Sixteen patients with acromegaly and PHP underwent rigorous genetic testing with DNA sequence analysis performed for genes including: MEN1, CDC73, CDKN1A, CDKN1B, CDKN2B, CDKN2C, and AIP, as well as MLPA to search for deletions or duplications in MEN1, CDC73, CDKN1B, and AIP genes. This evidence concerns the gene CDC73 and acromegaly.