While it is known that there is a higher prevalence of colon cancer in acromegaly, patients within the Acropara and isolated acromegaly groups had a high rate of biochemical control (85.3% and 90% normal IGF-1 at last follow-up, respectively) such that the prevalence of colon and other cancers may have been lower than prior reports (33, 34). This evidence concerns the gene IGF1 and colonic neoplasm.