The top ten hubs of the RA map as seen in Table 1 (NFKB, AKT, Inflammation, Cell chemotaxis/recruitment/infiltration, JUN, MAPK1, RAC1,2 Cell growth/Survival, Osteoclastogenesis, TP53) are well-characterized factors implicated in the disease. This evidence concerns the gene RAC1 and rheumatoid arthritis.