LAMB2 and familial pancreatic carcinoma: They include many genes related to extracellular matrix, collagens, laminins, integrins, fibronectin which are known mesenchymal markers [33] and matrix metalloproteinases which are involved in tumor growth, invasion and metastasis [34], as well as HMGA2 which is known to maintain oncogenic RAS-induced epithelial-mesenchymal transition (EMT) in pancreatic cancer [35].