MAPT and early-onset autosomal dominant Alzheimer disease: Abnormal hyperphosphorylated tau protein forms intracellular filamentous deposits, therefore resulting in a group of dementias termed tauopathies, such as Alzheimer’s disease (AD), frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), Pick’s disease (PiD), progressive supranuclear palsy (PSP), corticobasal degeneration, argyrophilic grain disease, globular glial tauopathy, and chronic traumatic encephalopathy [5].