Along these lines, another study in Burkitt's lymphoma cells reports that c‐Myc binds the E‐box sequences in the promoters of both ERN1 and XBP1 genes (Xie et al, 2018), establishing c‐Myc as a direct upstream regulator of the IRE1α‐XBP1s pathway. Here, ERN1 is linked to Burkitt lymphoma.