In glioblastoma, XBP1 splicing promotes tumor stroma remodeling, angiogenesis, and invasion, whereas IRE1α‐mediated RIDD for miR‐17 displays anti‐angiogenic and antimigratory effects, suggesting a dual role of IRE1 RNase in glioblastoma aggressiveness (Lhomond et al, 2018). Here, XBP1 is linked to glioblastoma.