In the mesenchymal pancreatic ductal adenocarcinoma mouse models with activated c‐Myc, constitutive knockdown of Ern1 potently impairs 3D clonogenic cell growth and suppresses tumorigenicity in orthotopic transplants in vivo (Genovese et al, 2017). This evidence concerns the gene ERN1 and pancreatic ductal adenocarcinoma.