Peripubertal DHT-induced PCOS female rats and mice exhibit elevated fasting blood glucose levels (116, 124, 125), decreased glucose tolerance (116, 244), and development of insulin resistance at adult age as measured by euglycemic hyperinsulinemic clamp, oral glucose tolerance test, and insulin tolerance test (96, 115, 122-125, 244). Here, INS is linked to polycystic ovary syndrome.