INS and polycystic ovary syndrome: They are also effective in improving cycles and androgen and LH levels in PNA mice (358), improving cycles and insulin-mediated glucoregulation in PNA sheep (281), and normalizing cycles while diminishing androgenic responsiveness to an hCG challenge and improving glucoregulation and lipids in PNA NHP (280), establishing a common insulin-driven mechanism exaggerating or causing metabolic and reproductive PCOS-like traits in animal models and PCOS traits in women.