PLOD1 and polycystic ovary syndrome: Thus, based on these findings, pharmacological antagonism aimed at tempering GnRH–LH secretion is an attractive therapeutic strategy to restore ovulation and fertility in women with PCOS characterized by high LH levels (> 75% of women with PCOS), given the fact that GnRH antagonists are already used in the clinic in adult subjects without reported deleterious side effects.