This mechanism agrees with findings in normal-weight PCOS patients of altered SC abdominal adipocyte stem cell gene expression of adipogenic/angiogenic functions involving T through TGF-β signaling (221), as well as in infant and adult visceral adipose tissue from early- to mid-gestation PNA NHP of differentially methylated genes involving TGF-β signaling (333), supporting a role for epigenomic programming in the etiology of PCOS. The gene discussed is TGFB1; the disease is polycystic ovary syndrome.