PLOD1 and polycystic ovary syndrome: In addition, 7 to 10 days of antiandrogen therapy normalizes progesterone negative feedback on LH pulse frequency in women with PCOS (359), 6 months of antiandrogen therapy normalizes menstrual cycles and reproductive hormones (274), and longer duration of application, commonly with other therapies including insulin sensitizers and oral contraceptives, have proven efficacious in improving menstrual cycle regularity and reproductive hormones (360) and hirsutism (361), respectively.