For example, in a recent study combining the adult DHT-induced model in pancreatic β-cell specific (βARKORIP) and neuron specific (nARKO) models together with a Western diet (DIO) as a metabolic stress, it was shown that DHT exposure predisposes to T2D via activation of hypothalamic AR causing hepatic insulin resistance, and activation of pancreatic β-cell AR leading to increased insulin secretion and β-cell failure (130). The gene discussed is INS; the disease is type 2 diabetes mellitus.