Increased LH pulse frequency, an elevated serum LH/FSH ratio, and greater pituitary LH responsiveness to GnRH in women with PCOS (31) are all likely due to an increased frequency of pulsatile GnRH secretion from neurons in the hypothalamus into the anterior pituitary portal venous drainage (3, 31, 193). The gene discussed is GNRH1; the disease is polycystic ovary syndrome.