With PCOM, the number of follicles 2 to 5 mm in diameter positively correlates with serum androgen levels, while the number of follicles 6 to 9 mm in diameter negatively correlates with fasting serum insulin and testosterone levels, as well as body mass index (BMI), suggesting that ovarian hyperandrogenism promotes excessive early follicular growth that does not progress to the dominant stage due to hyperinsulinemia and/or androgen excess (3). This evidence concerns the gene INS and hyperinsulinism.