AXIN2 and cancer: When compared to their heterozygous counterparts, WNT-reporterhi epidermal progenitors (α6 integrin+) that were null for Apc, displayed robust upregulation (Log2 Fold Change ≥ 1.5, p<0.05) of established WNT-target genes, for example Axin2, Twist1/2 and Bmp4, as well as transcripts associated with WNT signaling, cell-cell signaling, cancer, epithelial-mesenchymal transition and cell adhesion (Figure 2B–D and Figure 2—figure supplement 2).