This observation was consistent with the results of existing evidence that lnc‐MALAT1 was positively correlated with Scr, WBC, CRP, TNF‐α, IL‐8, IL‐17, APACHE II score, and SOFA score, while miR‐125 showed the opposite trend with these inflammatory cytokines and disease severity in sepsis patients.[15, 17] The possible reason might be that (a) according to one previous study, lnc‐MALAT1 might act as a regulator of NF‐κB signaling pathway, and inhibition of miR‐125a might stimulate classical activation of macrophages but suppress alternative activation polarization of macrophages. This evidence concerns the gene CXCL8 and Sepsis.