MALAT1 and Sepsis: Therefore, increased expression of lnc‐MALATA1/miR‐125a axis might elevate the pro‐inflammatory cytokines level, but decrease the anti‐inflammatory cytokines level.[20, 21] (b) In addition, lnc‐MALAT1/miR‐125a axis high expression might increase the production of pro‐inflammatory cytokines via mediating pro‐inflammatory transcriptional signaling, further leading to stimulation of LPS‐induced cell apoptosis and exacerbated septic organ injury, which contributed elevated general disease severity and organ injuries in sepsis patients.