In contrast, CMV-specific CD8+ T cells showed similar levels of degranulation in CLL compared to HC, in line with our earlier report on their functional cytotoxicity (Fig. 1F).8 Degranulation of EBV-specific CD8+ T cells is not impaired after PMA/Ionomycin stimulation, demonstrating there is no intrinsic functional defect in degranulation of EBV-specific CD8+ T cells in CLL (Supplementary Fig. 2A). Here, CD8A is linked to B-cell chronic lymphocytic leukemia.