CD4 and B-cell chronic lymphocytic leukemia: Although CLL has been shown to induce transcriptional changes in both the global CD4+ and CD8+ T cell compartments, the profound skewing of T cell differentiation states in CLL might obscure differences in specific T cell subsets between CLL patients and healthy controls (HC).7 Studying well defined T cell responses to specific antigens within the CLL environment may provide detailed insight in how CLL influences T cell function.