However, despite the fact that CLL affects gene expression in both virus-specific populations, the number of significantly altered genes that overlap and change in the same direction between CMV- and EBV-specific CD8+ T cells is relatively low (197 genes), demonstrating that these virus-specific populations are differentially affected in CLL (Fig. 4B). The gene discussed is CD8A; the disease is B-cell chronic lymphocytic leukemia.