Since CLL cells are known to have low mutational loads, CLL cells may not properly present neoantigens chronically in order for T cells to develop a classical exhausted phenotype.30,31 But, since CLL-neoantigen specific T cells are difficult to identify, quantitative and qualitative analyses of CLL-specific CD8+ T cell responses are lacking.31,32. The gene discussed is CD8A; the disease is B-cell chronic lymphocytic leukemia.