The relative frequency of EBV-specific CD8+ T cells within the global CD8+ T cell pool is not changed in CLL (Fig. 1B), but due to the increased absolute number of CD8+ T cells we observed an increase in the absolute number of EBV-specific CD8+ T cells in CLL patients (Fig. 1C). This evidence concerns the gene CD8A and B-cell chronic lymphocytic leukemia.