In addition, fibrinogen-γ chain mRNA is upregulated in the liver during inflammation.32Whereas CRP is a major acute-phase protein in human and rabbit, mouse CRP is not a major acute phase protein as determined by the measure of liver CRP mRNA concentrations after inflammatory stimuli.33Our data indicate that systemic inflammation is present in CKD mice following adenine diet but not in 5/6Nx mice, as demonstrated by the determination of both hepatic fibrinogen-γ chain mRNA and plasma fibrinogen. The gene discussed is CRP; the disease is chronic kidney disease.