TF and Renal insufficiency: The laser-induced injury model has been shown to stimulate thrombus formation without causing exposure of subendothelial collagens.43In this model, TF-mediated pathway of thrombin generation, by circulating microparticles and neutrophils, is the major pathway leading to platelet activation.44, 45Our data indicate that blood-borne TF and platelet functions are affected in renal insufficiency.