ADRB3 and hyperinsulinism: This finding is confirmed by a common genetic codon of Trp64 → Arg64 in ADRβ3, which can lead to metabolic abnormalities such as low levels of energy expenditure, high BMI (24), central obesity (25), hyperinsulinemia/IR (26), high blood pressure (BP) (27), type 2 diabetes (28), and even with gestational diabetes mellitus (29).