The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma; Lin28 inhibited let-7 family microRNA levels and upregulated the anti-apoptotic protein Bcl-xL, which is a target of let-7; Let-7c sensitizes acquired cisplatin-resistant A549 cells by targeting ABCC2 and Bcl-xL. This evidence concerns the gene BCL2L1 and hepatocellular carcinoma.