In contrast, when there is a chronic activation of immune response without any resolution of the damaged tissue, accumulation of regulatory T (Treg) cells, Th2 cells, and activated B cells is induced; these cells secrete pro-tumorigenesis factors (e.g. IL-4, IL-6, IL-10, IL-13, transforming growth factor beta - TGF-beta) that enhance pro-tumorigenesis responses in innate immune cells and inactivate CTL cytotoxicity, processes that favor tumor promotion3. The gene discussed is IL10; the disease is neoplasm.