ANXA2 and cancer: It has been found that HSP90α together with annexin II in exosomes impart cell motility to their cancer cells via an interaction with an extracellular tissue plasminogen activator (tPA), which in turn activates protease plasmin87.Similar to extracellular matrix remodelling, vascular destabilization at the pre-metastatic niche is indispensable for cancer cell dissemination from the primary tumor site.