Noteworthy, activation of FOXO proteins not only induces cell cycle arrest or apoptosis, but also a differentiation program.In chronic myeloid leukemia (CML), FOXO3 can induce CML leukemic cells differentiation, by inhibiting the expression of Id1 (Inhibitor of DNA binding 1). This evidence concerns the gene ID1 and chronic myelogenous leukemia, BCR-ABL1 positive.