Initially, FOXO1 transcription factor (previously known as FKHR-forkhead in rhabdomyosarcoma) was identified through its involvement in chromosomal translocations t(2;13) and t(1;13) in alveolar rhabdomyosarcoma tumors due to PAX3/7-FKHR fusion transcript16,17. Here, FOXO1 is linked to rhabdomyosarcoma.