FOXO3 and chronic myelogenous leukemia, BCR-ABL1 positive: Noteworthy, activation of FOXO proteins not only induces cell cycle arrest or apoptosis, but also a differentiation program.In chronic myeloid leukemia (CML), FOXO3 can induce CML leukemic cells differentiation, by inhibiting the expression of Id1 (Inhibitor of DNA binding 1).