The levels of total (AV+) and platelet- (CD61+) and leukocyte- (CD45+) derived AV+ cMVs increased in both groups during the study period, in addition to AV+ cMVs from activated cells (CD11b+) in the type 1 diabetes group; however, the change was only statistically significant for total and leukocyte-derived AV+ cMVs in the control group with Bonferroni correction (Supplementary ). This evidence concerns the gene ITGB3 and type 1 diabetes mellitus.