An induction of angiopoietin-2 and angiopoietin-1 in mouse host hippocampus cells was observed when donor bone marrow-derived human MSCs were transplanted in a model of cerebral ischemia and reperfusion [38], indicating an indirect effect on angiopoietin-2 expression similar to effects that we have observed. The gene discussed is ANGPT1; the disease is brain ischemia.