In this study, the finding that the AQP7 rs2989924 genotype variation was a risk factor for obesity-related diseases is consistent with findings of Prudente et al. However, the rs3758269 CT genotype in patients with BMI (kg/m2) ≥ 25 can reduce the risk of stroke compared with the CC genotype and the CT+TT vs. CC genotype (dominant model) after adjustment for potential confounders (OR 0.40, 95% CI 0.21-0.75 and OR 0.43, 95% CI 0.24-0.77, respectively). This evidence concerns the gene AQP7 and obesity due to melanocortin 4 receptor deficiency.