CD8A and Hyperglycemia: The negative regulation of cell activity during hyperglycemia is due to the decrease in CD4+/CD8+% and the enhanced expression of HLA-DR antigens [42], thus ensuring the stability of serum environmental glucose levels and possibly can avoid the interference with normal cells to execute normal activities, thereby ensuring their self-regulating function, shortening the inflammatory processes, and playing a positive effect on the body's immunity.