In mouse models of allergen-induced airway inflammation and acute pulmonary fibrosis, individual blockade of IL-25, IL-33, or TSLP was shown to have little influence on Th2-mediated pulmonary fibrosis, whereas blockade of all three cytokines significantly reduced inflammation, ILC2 recruitment, eosinophilia, and fibrosis in the lung, suggesting that combined targeting may be required to temper type 2-driven inflammation (Vannella et al., 2016). The gene discussed is IL25; the disease is Increased total eosinophil count.