For DEGs in profile 19 whose expression level increased with higher tumor grade, the top 20 enrichment KEGG path- ways mostly aggregated in well-known carcinogenesis pathways including microRNAs in cancer (13), PI3K-Akt signaling pathway (14), ECM-receptor interaction (15), proteoglycans in cancer (16), focal adhesion (17), HIF-1 signaling pathway (18), VEGF signaling pathway (19), cytokine-cytokine receptor interaction (20) etc. (Fig. 4A). This evidence concerns the gene HIF1A and neoplasm.