Although the detailed mechanism remained unclear, as is supported by our study results, down-regulated genes in starch and sucrose metabolism pathway or carbon metabolism pathway such as UGT1A and UGT2B (30), EHHADH (31), SHMT1 (32), ACAT1 (33), ACADS (31), ACADM (34) was previously reported to link with CRC. The gene discussed is SHMT1; the disease is colorectal carcinoma.