In addition, more implication was observed in fatty acid metabolism, fatty acid degradation, and fatty acid elongation pathway as many of their clustered DEGs were found to be potentially related to CRC oncogenesis or patient progression, such as EHHADH (31), ACAA2 (34), CPT2 (34), ACAT1 (33), ACADM (34), ELOVL4 (35), which reflected the damage of normal fatty acid intake and transformation and utilization pathway. Here, ACAT1 is linked to colorectal carcinoma.