The smallest region of overlap in 11q deletions has been reported between 11q14 and 11q23 (43) including genes such as CADM1 (11q23.3), and 4 genes involved in the DDR: ATM (11q22.3), CHK1 (11q24.2), MRE11 (11q21), and H2AFX (11q23.3), which have been functionally tested as candidate genes responsible for driving NB tumorigenesis [Figure 1; (44)]. The gene discussed is ATM; the disease is neuroblastoma.