STAT3 and hereditary disease: Other genetic disorders that lead to impaired TH17 development include dominant-negativeSTAT3 mutations underlying Job’s syndrome105, DOCK8 deficiency106, the recently described deficiency in ZNF341 (Table 1), a transcription factor that binds to the STAT3 promoter and results in defective STAT3 transcription and activity107,108, RORC deficiency60, andSTAT1 GOF109,110.