IGF1 and dry eye syndrome: Recent studies have reported the effectiveness of topical umbilical cord serum (TUCS) in treating ocular surface disorders, such as neurotrophic keratitis, dry eye syndrome, and persistent CEDs.[3,4,5] Several growth factors, such as the epidermal growth factor (EGF), acidic and basic fibroblast growth factors (FGFs), platelet-derived growth factor, hepatocyte growth factor, vitamin A, transforming growth factor-β (TGF- β), substance P, insulin-like growth factor-1 (IGF-1), nerve growth factor (NGF), fibronectin, and α2-macroglobulin, are present in umbilical cord serum (UCS).