Cornea has been the most transplanted tissue in Brazil since the late 1990s, with KC among the main etiologies.[39,40] Molecular and linkage studies have suggested multiple candidate genes that might underlie the development of KC.[32] In the present work, we found two non-synonymous mutations in LOX, namely Arg158Gln and Thr392Pro, and an intronic SOD1 deletion previously associated with KC development. This evidence concerns the gene SOD1 and keratoconus.