The implication of SOD1 and LOX mutations on KC development may be important risk factors for the disease and their involvement in disease pathogenesis depends on additional studies on different ethnicities.[25,33] Considering that this pathology is considered a major public health issue in Brazil, the aim of this study was to investigate the presence of genetic variants in SOD1 and LOX genes in individuals affected by advanced KC. This evidence concerns the gene SOD1 and keratoconus.