Anemia was noticed in 58 (43 %) patients, among whom, 31 (23 %) required blood transfusion (20 in IFN group and 11 in DAC group) while RBV dose was reduced in remaining 27 (20.3%) patients (10 in IFN group and 17 in DAC group). This evidence concerns the gene IFNA1 and anemia (phenotype).