This hypothesis is also supported by genetic evidence, as many of the mutations associated with ALS affect genes involved in UPS- or autophagy-mediated degradation, such as VCP, CHMP2B, progranulin (PGRN), OPTN, TMEM106B, SQSTM1, TBK1, UBQLN2, ALS2, and C9ORF72 [86, 126, 202–210]. The gene discussed is GRN; the disease is amyotrophic lateral sclerosis.