In human gastric cancer cells (HGC-27) and polymorphonuclear neutrophils, OME exerted an antitumoral effect through increase in caspase 3 [123], apoptotic proteins [90], and cleavage of poly [ADP-ribose] polymerase 1 (PARP-1) [124, 169, 170]; OME was cytotoxic in colon cells through increased gastrin secretion and increasing expression of IEX-1. The gene discussed is PARP1; the disease is gastric cancer.