The subsequent induction and expression of various inflammatory cytokines (TNF-α, IL-6, IL1β, IL-17, and IFN-γ) and enzymes (iNOS and COX-2) that are associated with the initiation and development of colitis 49, 79 were also prevented by low-dose IL-2 (Figure 3). The gene discussed is NOS2; the disease is colitis.