Notably, although co‐cultured CM significantly increased the level of phospho-STAT3 in MIA PaCa-2 and AsPC-1 cells targeted by the scrambled siRNA, cancer cells targeted by two STAT3-specific siRNAs exhibited impaired phospho-STAT3 induction following co-cultured CM treatment (Figure 4D, Figure S4G). Here, STAT3 is linked to cancer.