Functionally, liver parenchyma and vascular architecture distortion, collagen deposition and α-SMA+ myofibroblasts immune signal were consistently reduced in HF mice following pHBAAV-circFBXW4 administration (Figure 5C), a corresponding with the decreased protein expression of α-SMA and collagen I in HSCs (Figure 5D). Here, ACTA1 is linked to hydrops fetalis.