TP53 and ovarian carcinoma: Besides, Li et al. demonstrated that compound 15 showed a more potent cytotoxic to cisplatin-resistant ovarian cancer OVCAR-3 and A2780/CP70 cell lines than normal ovarian IOSE-364 cell line, by enhancing the p53-dependent caspase-8 activation extrinsic apoptosis pathway and inducing G2 cell cycle arrest via cyclin B1 by increasing p53 expression and p38 phosphorylation.