However, it is needed to note that compound 15 did not have effects on phospho-JNK and total JNK in inhibition of growth of OVCAR-3 and A2780/CP70 cells, which was different from mechanism of action in Ras-transformed epithelial and human carcinoma cells through inhibition of the JNK signaling pathway [34, 55]. Here, MAPK8 is linked to carcinoma.