Furthermore, studies of insulin therapy in cardiac patients had covered various groups as to their glycaemic status (healthy, type 2 diabetes, coronary artery disease), age (varying between 40.6 ± 1.8 and 65 ± 7 years), diabetes duration (nondiabetic to 11.5 ± 7.2 years), and BMI (25.2 ± 0.9 to 27 ± 2.4) [11–15]. This evidence concerns the gene INS and type 2 diabetes mellitus.